Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cdx2  caudal type homeobox 2   (Synonyms: Cdx-2)
Results	Reference
1	J:332401 Abuhashem A, Chivu AG, Zhao Y, Rice EJ, Siepel A, Danko CG, Hadjantonakis AK, RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription. Genes Dev. 2022 Aug 18;36(13-14):770-89
1	J:191079 Acampora D, Di Giovannantonio LG, Simeone A, Otx2 is an intrinsic determinant of the embryonic stem cell state and is required for transition to a stable epiblast stem cell condition. Development. 2013 Jan 1;140(1):43-55
1	J:238298 Acampora D, Omodei D, Petrosino G, Garofalo A, Savarese M, Nigro V, Di Giovannantonio LG, Mercadante V, Simeone A, Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast. Cell Rep. 2016 Jun 21;15(12):2651-64
1	J:326354 Allegre N, Chauveau S, Dennis C, Renaud Y, Meistermann D, Estrella LV, Pouchin P, Cohen-Tannoudji M, David L, Chazaud C, NANOG initiates epiblast fate through the coordination of pluripotency genes expression. Nat Commun. 2022 Jun 21;13(1):3550
1	J:330642 Andreu MJ, Alvarez-Franco A, Portela M, Gimenez-Llorente D, Cuadrado A, Badia-Careaga C, Tiana M, Losada A, Manzanares M, Establishment of 3D chromatin structure after fertilization and the metabolic switch at the morula-to-blastocyst transition require CTCF. Cell Rep. 2022 Oct 18;41(3):111501
1	J:293567 Azami T, Bassalert C, Allegre N, Valverde Estrella L, Pouchin P, Ema M, Chazaud C, Regulation of the ERK signalling pathway in the developing mouse blastocyst. Development. 2019 Jul 25;146(14):dev177139
1	J:325250 Bai D, Sun J, Chen C, Jia Y, Li Y, Liu K, Zhang Y, Yin J, Liu Y, Han X, Ruan J, Kou X, Zhao Y, Wang H, Wang Z, Chen M, Teng X, Jiang C, Gao S, Liu W, Aberrant H3K4me3 modification of epiblast genes of extraembryonic tissue causes placental defects and implantation failure in mouse IVF embryos. Cell Rep. 2022 May 3;39(5):110784
1	J:201097 Beraldo FH, Soares IN, Goncalves DF, Fan J, Thomas AA, Santos TG, Mohammad AH, Roffe M, Calder MD, Nikolova S, Hajj GN, Guimaraes AL, Massensini AR, Welch I, Betts DH, Gros R, Drangova M, Watson AJ, Bartha R, Prado VF, Martins VR, Prado MA, Stress-inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein. FASEB J. 2013 Sep;27(9):3594-607
1*	J:217512 Bessonnard S, De Mot L, Gonze D, Barriol M, Dennis C, Goldbeter A, Dupont G, Chazaud C, Gata6, Nanog and Erk signaling control cell fate in the inner cell mass through a tristable regulatory network. Development. 2014 Oct;141(19):3637-48
1	J:293009 Bhattacharya B, Home P, Ganguly A, Ray S, Ghosh A, Islam MR, French V, Marsh C, Gunewardena S, Okae H, Arima T, Paul S, Atypical protein kinase C iota (PKClambda/iota) ensures mammalian development by establishing the maternal-fetal exchange interface. Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14280-14291
1	J:108748 Chazaud C, Yamanaka Y, Pawson T, Rossant J, Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway. Dev Cell. 2006 May;10(5):615-24
1*	J:316935 Chen Z, Xie Z, Zhang Y, DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and pre-implantation development. Development. 2021 Dec 15;148(24):dev200178
1*	J:331055 Chousal JN, Sohni A, Vitting-Seerup K, Cho K, Kim M, Tan K, Porse B, Wilkinson MF, Cook-Andersen H, Progression of the pluripotent epiblast depends upon the NMD factor UPF2. Development. 2022 Nov 1;149(21):dev200764
1*	J:285737 Cui W, Cheong A, Wang Y, Tsuchida Y, Liu Y, Tremblay KD, Mager J, MCRS1 is essential for epiblast development during early mouse embryogenesis. Reproduction. 2020 Jan;159(1):1-13
1	J:344642 de la Rosa S, Del Mar Rigual M, Vargiu P, Ortega S, Djouder N, Endogenous retroviruses shape pluripotency specification in mouse embryos. Sci Adv. 2024 Jan 26;10(4):eadk9394
1	J:199467 Do DV, Ueda J, Messerschmidt DM, Lorthongpanich C, Zhou Y, Feng B, Guo G, Lin PJ, Hossain MZ, Zhang W, Moh A, Wu Q, Robson P, Ng HH, Poellinger L, Knowles BB, Solter D, Fu XY, A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo. Genes Dev. 2013 Jun 15;27(12):1378-90
1*	J:321237 Edwards NA, Watson AJ, Betts DH, P66Shc, a key regulator of metabolism and mitochondrial ROS production, is dysregulated by mouse embryo culture. Mol Hum Reprod. 2016 Sep;22(9):634-47
1*	J:149868 Ema M, Mori D, Niwa H, Hasegawa Y, Yamanaka Y, Hitoshi S, Mimura J, Kawabe Y, Hosoya T, Morita M, Shimosato D, Uchida K, Suzuki N, Yanagisawa J, Sogawa K, Rossant J, Yamamoto M, Takahashi S, Fujii-Kuriyama Y, Kruppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs. Cell Stem Cell. 2008 Nov 6;3(5):555-67
1	J:242105 Fiorenzano A, Pascale E, D'Aniello C, Acampora D, Bassalert C, Russo F, Andolfi G, Biffoni M, Francescangeli F, Zeuner A, Angelini C, Chazaud C, Patriarca EJ, Fico A, Minchiotti G, Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency. Nat Commun. 2016 Sep 02;7:12589
1	J:267922 Frum T, Murphy TM, Ralston A, HIPPO signaling resolves embryonic cell fate conflicts during establishment of pluripotency in vivo. Elife. 2018 Dec 11;7:e42298
1	J:337428 Funaya S, Wang Y, Suzuki MG, Ikawa M, Aoki F, Involvement of linker histone variant H1a in the regulation of early preimplantation development in mice. J Reprod Dev. 2023 Jun 6;69(3):178-182
1*	J:134633 Gao X, Tate P, Hu P, Tjian R, Skarnes WC, Wang Z, ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proc Natl Acad Sci U S A. 2008 May 6;105(18):6656-61
1*	J:237226 Ghule PN, Xie RL, Colby JL, Rivera-Perez JA, Jones SN, Lian JB, Stein JL, van Wijnen AJ, Stein GS, Maternal expression and early induction of histone gene transcription factor Hinfp sustains development in pre-implantation embryos. Dev Biol. 2016 Nov 15;419(2):311-320
1	J:240535 Goolam M, Zernicka-Goetz M, The chromatin modifier Satb1 regulates cell fate through Fgf signalling in the early mouse embryo. Development. 2017 Apr 15;144(8):1450-1461
1	J:242967 Gu B, Lambert JP, Cockburn K, Gingras AC, Rossant J, AIRE is a critical spindle-associated protein in embryonic stem cells. Elife. 2017 Jul 25;6:e28131
1*	J:194075 Guenatri M, Duffie R, Iranzo J, Fauque P, Bourc'his D, Plasticity in Dnmt3L-dependent and -independent modes of de novo methylation in the developing mouse embryo. Development. 2013 Feb 1;140(3):562-72
1*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
1*	J:294860 Han BY, Seah MKY, Brooks IR, Quek DHP, Huxley DR, Foo CS, Lee LT, Wollmann H, Guo H, Messerschmidt DM, Guccione E, Global translation during early development depends on the essential transcription factor PRDM10. Nat Commun. 2020 Jul 17;11(1):3603
1	J:256562 Hildebrand S, Hultin S, Subramani A, Petropoulos S, Zhang Y, Cao X, Mpindi J, Kalloniemi O, Johansson S, Majumdar A, Lanner F, Holmgren L, The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching. Sci Rep. 2017 Aug 25;7(1):9540
1	J:269584 Hupalowska A, Jedrusik A, Zhu M, Bedford MT, Glover DM, Zernicka-Goetz M, CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development. Cell. 2018 Dec 13;175(7):1902-1916.e13
1*	J:242195 Juan HC, Lin Y, Chen HR, Fann MJ, Cdk12 is essential for embryonic development and the maintenance of genomic stability. Cell Death Differ. 2016 Jun;23(6):1038-48
1	J:117056 Kan NG, Stemmler MP, Junghans D, Kanzler B, de Vries WN, Dominis M, Kemler R, Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm. Development. 2007 Jan;134(1):31-41
1	J:199283 Kaneko KJ, Depamphilis ML, TEAD4 establishes the energy homeostasis essential for blastocoel formation. Development. 2013 Sep;140(17):3680-90
1	J:226048 Kang J, Lienhard M, Pastor WA, Chawla A, Novotny M, Tsagaratou A, Lasken RS, Thompson EC, Surani MA, Koralov SB, Kalantry S, Chavez L, Rao A, Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4236-45
1	J:241994 Kang M, Garg V, Hadjantonakis AK, Lineage Establishment and Progression within the Inner Cell Mass of the Mouse Blastocyst Requires FGFR1 and FGFR2. Dev Cell. 2017 Jun 05;41(5):496-510.e5
1	J:286228 Kiyozumi D, Nakano I, Sato-Nishiuchi R, Tanaka S, Sekiguchi K, Laminin is the ECM niche for trophoblast stem cells. Life Sci Alliance. 2020 Feb;3(2)
1*	J:203997 Krawchuk D, Honma-Yamanaka N, Anani S, Yamanaka Y, FGF4 is a limiting factor controlling the proportions of primitive endoderm and epiblast in the ICM of the mouse blastocyst. Dev Biol. 2013 Dec 1;384(1):65-71
1	J:316936 Kubinyecz O, Santos F, Drage D, Reik W, Eckersley-Maslin MA, Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival. Development. 2021 Dec 15;148(24):dev200191
1*	J:316190 Lacko LA, Massimiani M, Sones JL, Hurtado R, Salvi S, Ferrazzani S, Davisson RL, Campagnolo L, Stuhlmann H, Novel expression of EGFL7 in placental trophoblast and endothelial cells and its implication in preeclampsia. Mech Dev. 2014 Aug;133:163-76
1	J:93217 Liu J, Puscheck EE, Wang F, Trostinskaia A, Barisic D, Maniere G, Wygle D, Zhong W, Rings EH, Rappolee DA, Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells. Reproduction. 2004 11;128(5):643-654
1*	J:336176 Mathew V, Mei A, Giwa H, Cheong A, Chander A, Zou A, Blanton RM, Kashpur O, Cui W, Slonim D, Mahmoud T, O'Tierney-Ginn P, Mager J, Draper I, Wallingford MC, hnRNPL expression dynamics in the embryo and placenta. Gene Expr Patterns. 2023 May 4;48:119319
1	J:326530 Mau KHT, Karimlou D, Barneda D, Brochard V, Royer C, Leeke B, de Souza RA, Pailles M, Percharde M, Srinivas S, Jouneau A, Christian M, Azuara V, Dynamic enlargement and mobilization of lipid droplets in pluripotent cells coordinate morphogenesis during mouse peri-implantation development. Nat Commun. 2022 Jul 5;13(1):3861
1*	J:182713 McDonel P, Demmers J, Tan DW, Watt F, Hendrich BD, Sin3a is essential for the genome integrity and viability of pluripotent cells. Dev Biol. 2012 Mar 1;363(1):62-73
1	J:232771 Messerschmidt D, de Vries WN, Lorthongpanich C, Balu S, Solter D, Knowles BB, beta-catenin-mediated adhesion is required for successful preimplantation mouse embryo development. Development. 2016 Jun 1;143(11):1993-9
1	J:241560 Molotkov A, Mazot P, Brewer JR, Cinalli RM, Soriano P, Distinct Requirements for FGFR1 and FGFR2 in Primitive Endoderm Development and Exit from Pluripotency. Dev Cell. 2017 Jun 05;41(5):511-526.e4
1*	J:147050 Nishioka N, Inoue K, Adachi K, Kiyonari H, Ota M, Ralston A, Yabuta N, Hirahara S, Stephenson RO, Ogonuki N, Makita R, Kurihara H, Morin-Kensicki EM, Nojima H, Rossant J, Nakao K, Niwa H, Sasaki H, The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev Cell. 2009 Mar;16(3):398-410
1*	J:130047 Nishioka N, Yamamoto S, Kiyonari H, Sato H, Sawada A, Ota M, Nakao K, Sasaki H, Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos. Mech Dev. 2008 Mar-Apr;125(3-4):270-83
1	J:290415 Ozguldez HO, Fan R, Bedzhov I, Placental gene editing via trophectoderm-specific Tat-Cre/loxP recombination. Development. 2020 Jul 3;147(13):dev190371
1	J:327416 Pailles M, Hirlemann M, Brochard V, Chebrout M, Oudin JF, Marks H, Jouneau A, Bonnet-Garnier A, H3K27me3 at pericentromeric heterochromatin is a defining feature of the early mouse blastocyst. Sci Rep. 2022 Aug 16;12(1):13908
1*	J:138816 Plusa B, Piliszek A, Frankenberg S, Artus J, Hadjantonakis AK, Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst. Development. 2008 Sep;135(18):3081-91
1*	J:325355 Rong Y, Zhu YZ, Yu JL, Wu YW, Ji SY, Zhou Y, Jiang Y, Jin J, Fan HY, Shen L, Sha QQ, USP16-mediated histone H2A lysine-119 deubiquitination during oocyte maturation is a prerequisite for zygotic genome activation. Nucleic Acids Res. 2022 Jun 10;50(10):5599-5616
1*	J:274844 Ruan Y, He J, Wu W, He P, Tian Y, Xiao L, Liu G, Wang J, Cheng Y, Zhang S, Yang Y, Xiong J, Zhao K, Wan Y, Huang H, Zhang J, Jian R, Nac1 promotes self-renewal of embryonic stem cells through direct transcriptional regulation of c-Myc. Oncotarget. 2017 Jul 18;8(29):47607-47618
1	J:331143 Sathyanarayanan A, Ing-Simmons E, Chen R, Jeong HW, Ozguldez HO, Fan R, Duethorn B, Kim KP, Kim YS, Stehling M, Brinkmann H, Scholer HR, Adams RH, Vaquerizas JM, Bedzhov I, Early developmental plasticity enables the induction of an intermediate extraembryonic cell state. Sci Adv. 2022 Nov 4;8(44):eabl9583
1	J:213580 Schrode N, Saiz N, Di Talia S, Hadjantonakis AK, GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst. Dev Cell. 2014 May 27;29(4):454-67
1*	J:343201 Srinivasan S, He X, Mirza S, Mager J, Exosome complex components 1 and 2 are vital for early mammalian development. Gene Expr Patterns. 2023 Nov 7;51:119346
1*	J:98502 Strumpf D, Mao CA, Yamanaka Y, Ralston A, Chawengsaksophak K, Beck F, Rossant J, Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development. 2005 May;132(9):2093-102
1*	J:327814 Suzuki D, Sasaki K, Kumamoto S, Tanaka K, Ogawa H, Dynamic Changes of Gene Expression in Mouse Mural Trophectoderm Regulated by Cdx2 During Implantation. Front Cell Dev Biol. 2022;10:945241
1*	J:172504 Szczepanska K, Stanczuk L, Maleszewski M, Isolated mouse inner cell mass is unable to reconstruct trophectoderm. Differentiation. 2011 Jul;82(1):1-8
1*	J:166346 Tolkunova E, Malashicheva A, Parfenov VN, Sustmann C, Grosschedl R, Tomilin A, PIAS proteins as repressors of Oct4 function. J Mol Biol. 2007 Dec 14;374(5):1200-12
1	J:290083 Uyhazi KE, Yang Y, Liu N, Qi H, Huang XA, Mak W, Weatherbee SD, de Prisco N, Gennarino VA, Song X, Lin H, Pumilio proteins utilize distinct regulatory mechanisms to achieve complementary functions required for pluripotency and embryogenesis. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):7851-7862
1*	J:136803 Wang H, Ding T, Brown N, Yamamoto Y, Prince LS, Reese J, Paria BC, Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse. Dev Biol. 2008 Jun 1;318(1):112-25
1	J:228855 Wicklow E, Blij S, Frum T, Hirate Y, Lang RA, Sasaki H, Ralston A, HIPPO pathway members restrict SOX2 to the inner cell mass where it promotes ICM fates in the mouse blastocyst. PLoS Genet. 2014 Oct;10(10):e1004618
1	J:171449 Williams LH, Kalantry S, Starmer J, Magnuson T, Transcription precedes loss of Xist coating and depletion of H3K27me3 during X-chromosome reprogramming in the mouse inner cell mass. Development. 2011 May;138(10):2049-57
1	J:201607 Wu G, Han D, Gong Y, Sebastiano V, Gentile L, Singhal N, Adachi K, Fischedick G, Ortmeier C, Sinn M, Radstaak M, Tomilin A, Scholer HR, Establishment of totipotency does not depend on Oct4A. Nat Cell Biol. 2013 Sep;15(9):1089-97
1*	J:165972 Wu X, Sandhu S, Patel N, Triggs-Raine B, Ding H, EMG1 is essential for mouse pre-implantation embryo development. BMC Dev Biol. 2010;10:99
1	J:342639 Xie G, Lee JE, Senft AD, Park YK, Jang Y, Chakraborty S, Thompson JJ, McKernan K, Liu C, Macfarlan TS, Rocha PP, Peng W, Ge K, MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner. Nat Genet. 2023 Apr;55(4):693-705
1	J:311921 Xu Y, Luo X, Fang Z, Zheng X, Zeng Y, Zhu C, Gu J, Tang F, Hu Y, Hu G, Jin Y, Li H, Transcription coactivator Cited1 acts as an inducer of trophoblast-like state from mouse embryonic stem cells through the activation of BMP signaling. Cell Death Dis. 2018 Sep 11;9(9):924
1*	J:126338 Yagi R, Kohn MJ, Karavanova I, Kaneko KJ, Vullhorst D, Depamphilis ML, Buonanno A, Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development. Development. 2007 Nov;134(21):3827-36
1*	J:259707 Ye B, Liu B, Hao L, Zhu X, Yang L, Wang S, Xia P, Du Y, Meng S, Huang G, Qin X, Wang Y, Yan X, Li C, Hao J, Zhu P, He L, Tian Y, Fan Z, Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Nat Commun. 2018 Mar 28;9(1):1261
1	J:256712 Yu C, Ji SY, Dang YJ, Sha QQ, Yuan YF, Zhou JJ, Yan LY, Qiao J, Tang F, Fan HY, Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse. Cell Res. 2016 Mar;26(3):275-87
1	J:145174 Zhang J, Tomasini AJ, Mayer AN, RBM19 is essential for preimplantation development in the mouse. BMC Dev Biol. 2008;8:115
1*	J:243181 Zhao T, Liu C, Chen L, Roles of Klf5 Acetylation in the Self-Renewal and the Differentiation of Mouse Embryonic Stem Cells. PLoS One. 2015;10(9):e0138168